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The quinolone drugs are touted as being the first synthetic or “man-made” antibiotics. This presentation demonstrates how our research indicates that the mechanism of action observed in quinolone drugs such as ciprofloxacin has been present and utilized by plants as an adaptation against infections. Furthermore, drugs and plants within the quinolone family should be used with discretion in order to avoid deleterious side effects and to prevent the spread of antibiotic resistant bacteria.